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ThermoFisher Scientific

Electron Microscopy Solutions

Basic life processes start in the cell. To understand how they function and respond to disease or genetic variations, life scientists engage in cellular and structural biology research. Cellular biology explores individual cells and the ways in which they are organized into organs and tissues. Structural biologists delve deep into sub-cellular components, organelles and macromolecular structures. Electron microscopy (EM) is capable of providing insight at all these scales and more, revealing even atomic-level structural details for a range of biomolecules.

Techniques

Single Particle Analysis

Cryo-Tomography

Micro ED

Large Volume Analysis

Integrative Structural Biology

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Cryo-Tomography

Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Large Volume Analysis

A novel serial block-face imaging (SBFI) solution that combines multi-energy deconvolution scanning electron microscopy (MED-SEM) with in situ sectioning. Automation and ease-of-use functions provide isotropic resolution for large volume samples.

Integrative Structural Biology

To understand protein function, you need complex and structure information beyond individual proteins. Integrative structural biology combines mass spectrometry and cryo EM for the determination of large dynamic complex structure.

Products

Desktop SEM

DualBeam

EFA Systems

Circuit Edit

Micro CT

Sample Vitrification

Software

Accessories

Scanning Electron Microscopy (SEM)

Axia ChemiSEM

Live quantitative elemental mapping

High fidelity scanning electron microscopy imaging

Flexible and easy to use, even for novice users

Easy maintenance

Verios 5 XHR SEM

Monochromated SEM for sub-nanometer resolution over the full 1 keV to 30 keV energy range

Easy access to beam landing energies as low as 20 eV

Excellent stability with piezo stage as standard

Quattro ESEM

Ultra-versatile high-resolution FEG SEM with unique environmental capability (ESEM)

Observe all information from all samples with simultaneous SE and BSE imaging in every mode of operation

Prisma E SEM

Entry-level SEM with excellent image quality

Easy and quick sample loading and navigation for multiple samples

Compatible with a wide range of materials thanks to dedicated vacuum modes

Apreo 2 SEM

High-performance SEM for all-round nanometer or sub-nanometer resolution

In-column T1 backscatter detector for sensitive, TV-rate materials contrast

Excellent performance at long working distance (10 mm)

VolumeScope 2 SEM

Isotropic 3D data from large volumes

High contrast and resolution in high and low vacuum modes

Simple switch between normal SEM use and serial block-face imaging

Desktop SEM

Phenom Pharos Desktop SEM

FEG source with 2 up to 15 kV acceleration voltage range

<2.5 nm (SE) and <4.0 nm (BSE) resolution @ 15 kV; up to 1,000,000x magnification

Optional fully integrated EDS and SE detector

Phenom XL G2 Desktop SEM

For large samples (100×100 mm) and ideal for automation

<10 nm resolution and up to 200,000x magnification; 4.8 kV up to 20 kV acceleration voltage

Optional fully integrated EDS and BSE detector

Phenom ProX Desktop SEM

High performance desktop SEM with integrated EDS detector

Resolution <8 nm (SE) and <10 nm (BSE); magnification up to 150,000x

Optional SE detector

Phenom Pro Desktop SEM

High performance desktop SEM

Resolution <8 nm (SE) and <10 nm (BSE); magnification up to 150,000x

Optional SE detector

Phenom Pure Desktop SEM

Entry level desktop SEM

Resolution <25 nm; magnification up to 65,000x

Longlife CeB6 source

Phenom Perception GSR Desktop SEM

Dedicated automated GSR desktop SEM

Resolution <10 nm; magnification up to 200,000x

Longlife CeB6 source

Phenom ParticleX AM Desktop SEM

Versatile desktop SEM with automation software for Additive Manufacturing

Resolution <10 nm; magnification up to 200,000x

Optional SE detector

Phenom ParticleX TC Desktop SEM

Versatile desktop SEM with automation software for Technical Cleanliness

Resolution <10 nm; magnification up to 200,000x

Optional SE detector

Phenom ParticleX Steel Desktop SEM

SEM and EDS integrated

Ease of use

Sub-micrometer inclusions

Transmission Electron Microscopy (TEM)

Krios Rx Cryo-TEM

Industry leading productivity and ease of use

Fixed 300 kV voltage for SPA only

Pharma-dedicated service package for guaranteed reliability

Krios G4 Cryo-TEM

Improved ergonomics

Fits more easily into new and existing labs

Maximized productivity and automation

Best image quality for high-resolution 3D reconstruction

Spectra 300 TEM

Highest-resolution structural and chemical information at the atomic level

Flexible high-tension range from 30-300 kV

Three lens condenser system

Spectra 200 TEM

High-resolution and contrast imaging for accelerating voltages from 30-200 kV

Symmetric S-TWIN/X-TWIN objective lens with wide-gap pole piece design of 5.4 mm

Sub-Angstrom STEM imaging resolution from 60 kV-200 kV

Glacios Cryo-TEM

Flexible Accelerating Voltage 80-200 kV

Industry-leading Autoloader for cryogenic sample manipulation

Small footprint

Enhanced ease-of-use

Talos Arctica TEM

Increased data acquisition speed

High data with robotic sample handling & automated loading

Unattended platform operation and automated data acquisition

Low cost of ownership with remote diagnostics and preventive service

Metrios AX TEM

Automation options to support quality, consistency, metrology, and reduced OPEX

Leverages machine learning for superior autofunctions and feature recognition

Workflows for both in-situ and ex-situlamella preparation

Themis ETEM

Precise control and knowledge of sample temperature

Improved sample stability, navigation, and assisted sample drift correction in x, y, and z axes

Advancing high-quality imaging and movie acquisition functions

Talos L120C TEM

Increased stability

4k × 4K Ceta CMOS camera

TEM magnification range from 25–650 kX

Flexible EDS analysis reveals chemical information

Talos F200i TEM

High-quality S/TEM images and accurate EDS

Available with dual EDS technology

Best all-round in situ capabilities

Large field-of-view imaging at high speed

Talos F200S TEM

Precise chemical composition data

High performance imaging and precise compositional analysis for dynamic microscopy

Features Velox Software for fast and easy acquisition and analysis of multimodal data

Talos F200X TEM

High resolution/throughput in STEM imaging and chemical analysis

Add application-specific in situ sample holders for dynamic experiments

Features Velox Software for fast and easy acquisition and analysis of multimodal data

Talos F200C TEM

Flexible EDS analysis reveals chemical information

High-contrast, high-quality TEM and STEM imaging

Ceta 16 Mpixel CMOS camera provides large field of view and high read-out speed

DualBeam

ExSolve WTP DualBeam

Can prepare site-specific, 20 nm thick lamellae on whole wafers up to 300 mm in diameter

Addresses needs requiring automated, high-throughput sampling at advanced technology nodes

Helios G4 EXL DualBeam

Precise control and knowledge of sample temperature

Improved sample stability, navigation, and assisted sample drift correction in x, y, and z axes

Advancing high-quality imaging and movie acquisition functions

Helios 5 DualBeam

Fully automated, high-quality, ultra-thin TEM sample preparation

High throughput, high resolution subsurface and 3D characterization

Rapid nanoprototyping capabilities

Helios 5 PFIB DualBeam

Gallium-free STEM and TEM sample preparation

Multi-modal subsurface and 3D information

Next-generation 2.5 μA xenon plasma FIB column

Helios 5 Laser PFIB System

Fast, millimeter-scale cross sections

Statistically relevant deep subsurface and 3D data analysis

Shares all capabilities of the Helios 5 PFIB platform

Helios Hydra DualBeam

4 fast switchable ion species (Xe, Ar, O, N) for optimized PFIB processing of a widest range of materials

Ga-free TEM sample preparation

Extreme high resolution SEM imaging

Aquilos 2 Cryo-FIB

Automation enables production of multiple lamellas

Target and extract your structure of interest with lift-out nano-manipulator

3D visualization for high-resolution tomography

Scios 2 DualBeam

Full support of magnetic and non-conductive samples

High throughput subsurface and 3D characterization

Advanced ease of use and automation capabilities

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Contact & Appointment

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